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Since they were first reported in 1975, monoclonal antibodies have developed from tools in basic research, to diagnostic agents, and more recently, with humanization, to the status of bona fide therapeutic agents. Nature Biotechnology, Nature Medicine and Nature Cell Biology present a focus on monoclonal antibodies, covering basic, technological and clinical aspects of their use, and stretching across fields that range from transplantation tolerance to colon cancer.

The variety of articles presented is designed to reflect the diverse content of these three journals. The importance and breadth of monoclonal antibody applications is reflected in the fact that this reagent surfaces frequently throughout the Nature family of journals – gratifyingly, with ever-increasing frequency in the clinical arena. More examples of recent research papers where monoclonal antibodies have a central role can be found in the "Nature Journals' Selection" section of this website; selected articles are free for a period of six months.