Dictyostelium discoideum genome

In this focus

The slime mould Dictyostelium discoideum has been an important laboratory model for over 50 years. These social amoebae normally live in forest soil where they hunt bacteria and yeast, and have therefore excelled in studies of how cells sense and move towards attractants in their environment. When hunting is not successful, the unicellular organisms become one multicellular entity and form a fruiting body to disperse spores, shown on the cover image. Here, Nature presents analysis of the genome and proteome of Dictyostelium, available free. We also provide an archive of related papers and links to major Dicty resources.


Current research articles

The genome of the social amoeba Dictyostelium discoideum Free access

Eichinger L., et al.

Nature 435, 43-57 (4 May 2005) doi:10.1038/nature03481



Epistasis analysis with global transcriptional phenotypes.

Van Driessche N. et al.

Nature Genetics 37, 471-477 (10 Apr 2005) doi:10.1038/ng1545

Pleiotropy as a mechanism to stabilize cooperation.

Foster K. R., Shaulsky G., Strassmann J. E., Queller D. C. & Thompson C. R.

Nature 431, 693-696 (7 Oct 2004) doi:10.1038/nature02894

Functions of LIM proteins in cell polarity and chemotactic motility.

Khurana B., Khurana T., Khaire N. & Noegel A.A.

EMBO J. 21, 5331-5342 (15 Oct 2002) doi:10.1093/emboj/cdf550

Sequence and analysis of chromosome 2 of Dictyostelium discoideum Free access

Glockner G. et al.

Nature 418, 79-85 (04 Jul 2002) doi:10.1038/nature00847

A common mechanism of action for three mood-stabilizing drugs.

Williams R.S.B., Cheng L., Mudge A.W. & Harwood A.J.

Nature 417, 292-295 (16 May 2002) doi:10.1038/417292a

Altruism and social cheating in the social amoeba Dictyostelium discoideum.

Strassmann J.E., Zhu Y. & Queller D.C.

Nature 408, 965-967 (21 Dec 2000) doi:10.1038/35050087

Ca2+ signalling is not required for chemotaxis in Dictyostelium.

Traynor D., Milne J.L.S., Insall R.H. & Kay R.R.

EMBO J. 19, 4846-4854 (01 Sep 2000) doi:10.1093/emboj/19.17.4846

A new anatomy of the prestalk zone in Dictyostelium.

Roos W., Scheidegger C. & Gerish G.

Nature 340, 144-146 (13 Jul 1989) doi:10.1038/340144a0

Adenylate cyclase activity oscillations as signals for cell aggregation in Dictyostelium discoideum.

Roos W., Scheidegger C. & Gerish G.

Nature 266, 259-261 (1977)

Cell differentiation without morphogenesis in Dictyostelium discoideum.

Town C.D., Gross J.D. & Kay R.R.

Nature 262, 717-719 (1976)

Synthesis of cyclic AMP in Dictyostelium discoideum and Polysphondylium pallidum.

Konijn T.M., Chang Y.Y. & Bonner J.T.

Nature 224, 1211-1212 (1969)