Supplements

RNA silencing

Vol. 457, No. 7228 pp 395–433

RNA silencing cover

In this supplement

In the past decade, the idea that RNA is just a passive carrier of information has been overturned. Small non-coding RNA molecules are now known to be important regulators of gene expression and genome integrity. With recent technological advances, the molecular mechanisms of these RNA silencing pathways are becoming clearly defined, and their components are now being tested in clinical trials.

Top

Editorial

RNA silencing free access

Angela K. Eggleston

doi:10.1038/457395a


Top

Reviews

On the road to reading the RNA-interference code

Haruhiko Siomi & Mikiko C. Siomi

doi:10.1038/nature07754


A three-dimensional view of the molecular machinery of RNA interference

Martin Jinek & Jennifer A. Doudna

doi:10.1038/nature07755


Small RNAs in transcriptional gene silencing and genome defence

Danesh Moazed

doi:10.1038/nature07756


Viral and cellular messenger RNA targets of viral microRNAs

Bryan R. Cullen

doi:10.1038/nature07757


The promises and pitfalls of RNA-interference-based therapeutics

Daniela Castanotto & John J. Rossi

doi:10.1038/nature07758


Top