Post-transcriptional control

Genes that encode various RNAs are transcribed in the nucleus (although some are transcribed in mitochondria) by RNA polymerase I, II or III, but the primary transcripts are virtually never the mature, active species. These precursor RNAs must therefore undergo post-transcriptional processing; for pre-mRNAs this involves 5' capping, 3' polyadenylation, pre-mRNA splicing and in some cases RNA editing. The concentration of mature mRNA in the cytoplasm — which in turn depends on mRNA transport and RNA quality-control, storage and degradation mechanisms — determines the rate of translation.

Post-transcriptional regulation of gene expression is much more intricate than previously thought, and elucidating the basic mechanisms of post-transcriptional control will be essential to gain a full understanding of how gene expression is regulated at different levels, of the interplay between these mechanisms, and of the extensive involvement of post-transcriptional dysfunction in numerous genetic disorders and cancer. Although we will focus in this Article Series mostly on post-transcriptional events involving mRNA, non-coding RNA-mediated post-transcriptional control will also be discussed.



July 2010 Vol 11 No 7

All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay

Joel G. Belasco

May 2010 Vol 11 No 5

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjá vu

Felix Tritschler, Eric Huntzinger & Elisa Izaurralde

February 2010 Vol 11 No 2

The mechanism of eukaryotic translation initiation and principles of its regulation

Richard J. Jackson, Christopher U. T. Hellen & Tatyana V. Pestova



November 2009 Vol 10 No 11

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Mo Chen & James L. Manley

June 2009 Vol 10 No 6

RNA granules: post-transcriptional and epigenetic modulators of gene expression

Paul Anderson & Nancy Kedersha

February 2009 Vol 10 No 2

Biogenesis of small RNAs in animals

V. Narry Kim, Jinju Han & Mikiko C. Siomi

February 2009 Vol 10 No 2

Revisiting the principles of microRNA target recognition and mode of action

Peter Brodersen & Olivier Voinnet



December 2008 Vol 9 No 12

Translational control of localized mRNAs: restricting protein synthesis in space and time

Florence Besse & Anne Ephrussi

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Multifunctional deadenylase complexes diversify mRNA control

Aaron C. Goldstrohm & Marvin Wickens

A structural understanding of the dynamic ribosome machine

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Exporting RNA from the nucleus to the cytoplasm

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The highways and byways of mRNA decay

Nicole L. Garneau Jeffrey Wilusz & Carol J. Wilusz

P bodies: at the crossroads of post-transcriptional pathways

Ana Eulalio, Isabelle Behm-Ansmant and Elisa Izaurralde

Editor meets silencer: crosstalk between RNA editing and RNA interference

Kazuko Nishikura

RNA-quality control by the exosome

Jonathan Houseley, John LaCava & David Tollervey

Early nonsense: mRNA decay solves a translational problem

Nadia Amrani, Matthew S. Sachs & Allan Jacobson